前列地尔联合厄贝沙坦治疗糖尿病肾病患者的临床效果

目的探讨前列地尔联合厄贝沙坦治疗糖尿病肾病患者的临床效果。方法选取2018年2月至2020年2月在辽宁省精神卫生中心进行药物治疗的94例糖尿病肾病患者作为研究对象,随机分为对照组与观察组,每组47例。对照组采用厄贝沙坦片进行治疗,观察组采用前列地尔联合厄贝沙坦片进行治疗。比较两组治疗有效率、药物不良反应发生率、血糖、血肌酐、尿素氮、24 h尿微量白蛋白、24 h尿蛋白、糖尿病肾病症状消失时间、肾功能指标复常时间、住院时间。结果观察组治疗有效率为91.5%,高于对照组的72.3%,差异有统计学意义(P<0.05);观察组患者2例(4.2%)发生药物不良反应,对照组9例(19.3%),组间比较差异有统计学意义(P<0.05);治疗后,两组空腹血糖、餐后2h血糖、血肌酐、尿素氮、24 h尿微量白蛋白、24 h尿蛋白水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组糖尿病肾病症状消失时间、肾功能指标检查结果恢复正常时间、住院时间明显短于对照组,差异有统计学意义(P<0.05)。结论前列地尔联合厄贝沙坦治疗糖尿病肾病患者的临床效果显著,可短时间内使患者肾功能和血糖水平得到改善,降低药物不良反应发生率,缩短患者住院时间。     

基于改进的灰色模型对货物周转量的预测——以云南省货物周转量为例

现代物流业作为中国现代服务业的重要组成部分,对提高国民经济运营质量、优化经济流程、调整经济结构、扩大内需、增进社会福利等都具有全局性的积极影响。它也逐渐被认为是继降低物资消耗、提高劳动生产率之后的又一重要的利润源泉。货物周转量的衡量与计算比较容易,而货物周转量与物流量之间的关系,使得对于物流周转量的预测显得十分必要。     

基于物质流分析的京津冀区域物质代谢研究

本文研究运用物质流分析方法,以京津冀地区作为研究对象,构建区域物质代谢分析指标,实证分析了京津冀地区2005～2012年间的物质代谢规模、强度、效率。结果表明：（1）京津冀物质代谢规模呈上升趋势,河北省物质代谢规模明显大于北京和天津;（2）河北和天津物质代谢强度呈上升趋势,北京市物质代谢强度呈下降趋势,且整体上低于河北和天津;（3）京津冀物质生产力2012年相比2005年分别提高了114.63%、74.8%和14.28%,环境效率分别提高了17548%、86.65%、7.21%。研究结果可为京津冀协同发展提供科学依据和指导,也为该区域可持续发展研究奠定了基础。     

矿产资源开发的物质流分析

在界定矿产资源开发物质代谢含义的基础上,从复杂性、可控性、连续性、差异性等方面分析了矿产资源开发物质代谢的特征.认为开展矿产资源开发的物质流分析可以为矿产资源开发环境压力分析提供依据、为矿业循环经济的发展提供支持.从矿产资源开发物质流分析原则出发,提出了矿产资源开发物质流分析的方法、构建了矿产资源开发物质流分析的账户体系及指标体系.     

Socio-ecological regime transitions in Austria and the United Kingdom

We employ the concepts of socio-ecological regime and regime transition to better understand the biophysical causes and consequences of industrialization. For two case studies, the United Kingdom and Austria we describe two steps in a major transition from an agrarian to an industrial socio-ecological regime and the resulting consequences for energy use, land use and labour organization. In a first step, the coal based industrial regime co-existed with an agricultural sector remaining within the bounds of the old regime. In a second step, the oil/electricity based industrial regime, agriculture was integrated into the new pattern and the socio-ecological transition had been completed. Industrialization offers an answer to the input and growth related sustainability problems of the agrarian regime but creates new sustainability problems of a larger scale. While today's industrial societies are stabilizing their resource use albeit at an unsustainable level large parts of the global society are in midst of the old industrial transition. This poses severe problems for global sustainability.     

Urban Political Ecology Beyond Methodological Cityism

The concept of planetary urbanization has emerged in recent years amongst neo‐Lefebvrian urban scholars who see urbanization as a process taking place at all spatial scales. This article analyses recent critiques of the urban political ecology (UPE) literature which argue that much of the work in the field has been guilty of focusing exclusively on the traditional bounded city unit rather than urbanization as a process. In response, the article reviews various strands of the UPE literature which have (always) moved beyond ‘the city’ to consider the various metabolisms and circulations of humans and non‐humans connecting cities with places outside of their borders at a variety of scales. Furthermore, it suggests how these approaches can productively work with the insights of the planetary urbanization literature, in considering both the changing nature of urbanization and also the socio‐ecological and political implications of these changes. Finally, the article suggests how the methodological approach of the ‘site multiple’ and its focus on everyday practices and lived experiences can be useful for researching diverse urban phenomena and their more‐than‐urban connections.     

基于新陈代谢GM-Markov模型的股价预测

本文建立了新陈代谢GM-Markov模型。该模型很好地吸收了GM模型及Markov模型的优点,同时新陈代谢的作用保证了不断加入新信息而去除旧信息,从而提高了模型的预测精度,预测结果与实际状况基本相符,这说明用该模型来预测股票价格走势是可行的。     

葡萄糖酸钠的制备及发展趋势

概述了葡萄糖酸钠的基本特性和用途,综述了以葡萄糖为基本原料制备葡萄糖酸钠的4种合成方法——生物发酵法、均相化学氧化法、电解氧化法、多相催化氧化法。通过比较认为多相催化氧化法更适用于工业化生产。介绍了多相催化氧化法所使用的钯炭催化剂。     

矿井绝对瓦斯涌出量的新陈代谢GM(1,1)预测

简要论述了瓦斯涌出量预测方法,结合国内实际,提出灰色模型预测方法,并根据该矿过去十年的瓦斯绝对涌出量资料建立了新陈代谢GM(1,1)模型。通过模型的求解,给出预测结果,并对结果进行检验。而且将未来5年的瓦斯绝对涌出量预测值用折线图画出,分析了其总体趋势并给出大体的建议。     

Cost-effectiveness of G5 Mobile continuous glucose monitoring device compared to self-monitoring of blood glucose alone for people with type 1 diabetes from the Canadian societal perspective

Aims: To evaluate the cost-effectiveness of real-time continuous glucose monitoring (CGM) compared to self-monitoring of blood glucose (SMBG) alone in people with type 1 diabetes (T1DM) using multiple daily injections (MDI) from the Canadian societal perspective.

Methods: The IMS CORE Diabetes Model (v.9.0) was used to assess the long-term (50 years) cost-effectiveness of real-time CGM (G5 Mobile CGM System; Dexcom, Inc., San Diego, CA) compared with SMBG alone for a cohort of adults with poorly-controlled T1DM. Treatment effects and baseline characteristics of patients were derived from the DIAMOND randomized controlled clinical trial; all other assumptions and costs were sourced from published research. The accuracy and clinical effectiveness of G5 Mobile CGM is the same as the G4 Platinum CGM used in the DIAMOND randomized clinical trial. Base case assumptions included (a) baseline HbA1c of 8.6%, (b) change in HbA1c of –1.0% for CGM users vs –0.4% for SMBG users, and (c) disutilities of –0.0142 for non-severe hypoglycemic events (NSHEs) and severe hypoglycemic events (SHEs) not requiring medical intervention, and –0.047 for SHEs requiring medical resources. Treatment costs and outcomes were discounted at 1.5% per year.

Results: The incremental cost-effectiveness ratio for the base case G5 Mobile CGM vs SMBG was $33,789 CAD/quality-adjusted life-year (QALY). Sensitivity analyses showed that base case results were most sensitive to changes in percentage reduction in hypoglycemic events and disutilities associated with hypoglycemic events. The base case results were minimally impacted by changes in baseline HbA1c level, incorporation of indirect costs, changes in the discount rate, and baseline utility of patients.

Conclusions: The results of this analysis demonstrate that G5 Mobile CGM is cost-effective within the population of adults with T1DM using MDI, assuming a Canadian willingness-to-pay threshold of $50,000 CAD per QALY.